Effects of Heavy Ion Radiation on Epithelial Cell Membranes

Fig. 1. Determination of the development of transepithelial resistance (TER) in cells irradiated with Carbon 290 MeV/u ions (a), Neon 400 MeV/u ions (b), and gamma rays (c). Figures illustrate the level of TER in non-irradiated control cells (circle), and cells irradiated with 5 Gy (solid circle), 10 Gy (square) and 25 Gy (solid square) doses. TER is expressed in ohms cm2. Data represent the mean ± the standard error of n = 6 cell monolayers.

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Fig. 2. Comparison of the effects of different qualities of radiation on TER at irradiation doses of 5 Gy (a), 10 Gy (b), and 25 Gy (c). Values are indicated as percentages of non-irradiated control TER for Carbon 290 MeV/u (square), Neon 400 MeV/u (triangle), and gamma rays (solid circle). Data represent the mean of n = 6 cell monolayers.

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Fig. 3. Chemoprotection against irradiation damage. This figure illustrates the comparison of effectiveness of chemoprevention cocktail as determined by TER measurements in cells irradiated with a 25 Gy dose of Carbon 290 MeV/u ions (a), Neon 400 MeV/u ions (b), and gamma rays (c). Cells were irradiated and maintained thereafter in the presence (solid square) or absence (square) of the chemopreventive cocktail. TER is expressed in ohms cm2. Data represent the mean ± the standard error of n = 6 cell monolayers.

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Fig. 4. Chemoprotection against irradiation damage. This figure illustrates the comparison of effectiveness of chemoprevention cocktail as determined by TER measurements in cells irradiated with a 10 Gy dose of Carbon 290 MeV/u ions (a), Neon 400 MeV/u ions (b), and gamma rays (c). Cells were irradiated and maintained thereafter in the presence (solid square) or absence (square) of the chemopreventive cocktail. TER is expressed in ohms cm2. Data represent the mean ± the standard error of n = 6 cell monolayers.

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Fig. 5. Effect of the different types of radiation on the TER of cells treated with chemopreventive cocktail. Cells were irradiated at doses of 10 Gy (a) and 25 Gy (b). Values are indicated as percentages of TER control for Carbon 290 MeV/u (square), Neon 400 MeV/u (triangle) and gamma rays (solid circle). Data represent the mean of n = 6 cell monolayers.

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Contents
ISSO -- Institute for Space Systems Operations
1997-1998 Annual Report